B-cells and regulatory T-cells in the microenvironment of HER2+ breast cancer are associated with decreased survival: a real-world analysis of women with HER2+ metastatic breast cancer

B-cells and regulatory T-cells in the microenvironment of HER2+ breast cancer are associated with decreased survival: a real-world analysis of women with HER2+ metastatic breast cancer

Abstract Background Despite major improvements in treatment of HER2-positive metastatic breast cancer (MBC), only few patients achieve complete remission and remain progression free for a prolonged time. The tumor immune microenvironment plays an important role in the response to treatment in HER2-p...

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Bibliographic Details
Main Authors: Tessa G. Steenbruggen, Denise M. Wolf, Michael J. Campbell, Joyce Sanders, Sten Cornelissen, Bram Thijssen, Roberto A. Salgado, Christina Yau, Nick O-Grady, Amrita Basu, Rajith Bhaskaran, Lorenza Mittempergher, Gillian L. Hirst, Jean-Philippe Coppe, Marleen Kok, Gabe S. Sonke, Laura J. van ‘t Veer, Hugo M. Horlings
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Breast Cancer Research
Subjects:
HER2-positive
Metastatic breast cancer
Tumor immune microenvironment
Multiplex immunofluorescence
Spatial composition
Gene expression
Online Access:https://doi.org/10.1186/s13058-023-01717-1

Internet

https://doi.org/10.1186/s13058-023-01717-1

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