Development of Phosphodiesterase–Protein-Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity

Development of Phosphodiesterase–Protein-Kinase Complexes as Novel Targets for Discovery of Inhibitors with Enhanced Specificity

Phosphodiesterases (PDEs) hydrolyze cyclic nucleotides to modulate multiple signaling events in cells. PDEs are recognized to actively associate with cyclic nucleotide receptors (protein kinases, PKs) in larger macromolecular assemblies referred to as signalosomes. Complexation of PDEs with PKs gene...

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Bibliographic Details
Main Authors: Nikhil K. Tulsian, Valerie Jia-En Sin, Hwee-Ling Koh, Ganesh S. Anand
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
phosphodiesterase (PDE)
natural products
inhibitors
protein kinase
selectivity
fluorescence polarization
Online Access:https://www.mdpi.com/1422-0067/22/10/5242

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https://www.mdpi.com/1422-0067/22/10/5242

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