No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan‐induced inhibition of platelet aggregation response

No impact of polymorphism in the phosphodiesterase 5A gene in Cavalier King Charles Spaniels on pimobendan‐induced inhibition of platelet aggregation response

Abstract Background A variant in the canine phosphodiesterase (PDE) 5A gene (PDE5A:E90K) is associated with decreased concentrations of circulating cyclic guanosine monophosphate (cGMP) and response to PDE5 inhibitor treatment. Pimobendan is a PDE inhibitor recommended for medical treatment of certa...

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Bibliographic Details
Main Authors: Maria J. Reimann, Daniel N. Faisst, Mads Knold, Kathryn M. Meurs, Joshua A. Stern, Signe E. Cremer, Jacob E. Møller, Ingrid Ljungvall, Jens Häggström, Lisbeth H. Olsen
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Journal of Veterinary Internal Medicine
Subjects:
dogs
genetic variation
heart disease
light transmission aggregometry
pharmacogenetics
platelet inhibition
Online Access:https://doi.org/10.1111/jvim.16871

Internet

https://doi.org/10.1111/jvim.16871

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