Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies

Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies

We explored the molecular evolution of the spike gene after the administration of anti-spike monoclonal antibodies in patients with mild or moderate forms of COVID-19. Four out of the 13 patients acquired a mutation during follow-up; two mutations (G1204E and E406G) appeared as a mixture without cli...

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Bibliographic Details
Main Authors: Aude Jary, Stéphane Marot, Antoine Faycal, Sacha Leon, Sophie Sayon, Karen Zafilaza, Emna Ghidaoui, Stéphanie Nguyen Quoc, Safaa Nemlaghi, Sylvain Choquet, Martin Dres, Valérie Pourcher, Vincent Calvez, Helga Junot, Anne-Geneviève Marcelin, Cathia Soulié
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Viruses
Subjects:
COVID-19
SARS-CoV-2
monoclonal antibodies therapy
spike gene
immune escape mutation
Q493R
Online Access:https://www.mdpi.com/1999-4915/14/2/226

Internet

https://www.mdpi.com/1999-4915/14/2/226

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