Rescue of cell cycle progression in BRAF inhibitor–resistant human melanoma by a chromatin modifier
The BRAF V600E -specific inhibitor vemurafenib blocks mitogen-activated protein kinase pathway and induces cell cycle arrest at G0/G1 phase leading to apoptosis of melanomas. To gain an understanding of the dynamics of cell cycle regulation during vemurafenib therapy, we analyzed several vemurafenib...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOS Press
2017-09-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317721620 |