Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

Abstract The adoptive transfer of regulatory T cells is a promising strategy to prevent graft-versus-host disease after allogeneic bone marrow transplantation. Here, we use a major histocompatibility complex-mismatched mouse model to follow the fate of in vitro expanded donor regulatory T cells upon...

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Bibliographic Details
Main Authors: David J. Dittmar, Franziska Pielmeier, Nicholas Strieder, Alexander Fischer, Michael Herbst, Hanna Stanewsky, Niklas Wenzl, Eveline Röseler, Rüdiger Eder, Claudia Gebhard, Lucia Schwarzfischer-Pfeilschifter, Christin Albrecht, Wolfgang Herr, Matthias Edinger, Petra Hoffmann, Michael Rehli
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47575-z

Internet

https://doi.org/10.1038/s41467-024-47575-z

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