CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Myelinating cells differentially myelinate axons of different diameters, however whether they can also restrict radial axonal growth remained unclear. Here, the authors show that CMTM6 in Schwann cells restricts axon diameters, affecting sensory nerve conduction and behavioral performance.

Bibliographic Details
Main Authors: Maria A. Eichel, Vasiliki-Ilya Gargareta, Elisa D’Este, Robert Fledrich, Theresa Kungl, Tobias J. Buscham, Katja A. Lüders, Cristina Miracle, Ramona B. Jung, Ute Distler, Kathrin Kusch, Wiebke Möbius, Swen Hülsmann, Stefan Tenzer, Klaus-Armin Nave, Hauke B. Werner
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18172-7

Internet

https://doi.org/10.1038/s41467-020-18172-7

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