Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

In the recent past, about 40 botulinum neurotoxin (BoNT) subtypes belonging to serotypes A, B, E, and F pathogenic to humans were identified among hundreds of independent isolates. BoNTs are the etiological factors of botulism and represent potential bioweapons; however, they are also recognized pha...

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Bibliographic Details
Main Authors: Stefan Sikorra, Martin Skiba, Martin B. Dorner, Jasmin Weisemann, Mirjam Weil, Sylvia Valdezate, Bazbek Davletov, Andreas Rummel, Brigitte G. Dorner, Thomas Binz
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Toxins
Subjects:
Clostridium botulinum
botulinum neurotoxin
serotype F
subtype
vesicle associated membrane protein 2 (VAMP-2)
synaptobrevin
Zn2+ protease
Online Access:http://www.mdpi.com/2072-6651/10/8/311

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http://www.mdpi.com/2072-6651/10/8/311

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