462 Dysfunctional leukocyte mitochondrial metabolism is associated with immune paralysis in critically ill septic patients

OBJECTIVES/GOALS: The host immune response during sepsis is now recognized to have anti-inflammatory pathophysiology. We aim to determine whether mitochondrial dysfunction of leukocytes predicts which critically ill septic patients develop immune paralysis and to identify differences in cellular met...

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Bibliographic Details
Main Authors: Lisa K Torres, Keith McConn, Luis Gomez-Escobar, Suzanne Cloonan, Augustine MK Choi
Format: Article
Language:English
Published: Cambridge University Press 2022-04-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S2059866122002710/type/journal_article