Mutation network-based understanding of pleiotropic and epistatic mutational behavior of Enterococcus faecalis FMN-dependent azoreductase

Mutation network-based understanding of pleiotropic and epistatic mutational behavior of Enterococcus faecalis FMN-dependent azoreductase

We previously identified a highly active homodimeric FMN-dependent NADH-preferred azoreductase (AzoA) from Enterococcus faecalis, which cleaves the azo bonds (R-N˭N-R) of diverse azo dyes, and determined its crystal structure. The preliminary network-based mutational analysis suggested that the two...

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Bibliographic Details
Main Authors: Jinyan Sun, Ohgew Kweon, Jinshan Jin, Gui-Xin He, Xiyu Li, Carl E. Cerniglia, Huizhong Chen
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Azoreductase
Azo dye
Pleiotropy
Epistasis
Mutation network
Rational design
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817302194

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http://www.sciencedirect.com/science/article/pii/S2405580817302194

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