Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin

Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin

Abstract The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most frequently observed, which limits the anti-tumor efficie...

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Bibliographic Details
Main Authors: Guifeng Su, Dan Wang, Qianqing Yang, Lingmei Kong, Xiaoman Ju, Qihong Yang, Yiying Zhu, Shaohua Zhang, Yan Li
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:Natural Products and Bioprospecting
Subjects:
Colorectal cancer
Wnt/β-catenin
APC
CEP
Transcriptional inhibitor
Online Access:https://doi.org/10.1007/s13659-024-00443-1

Internet

https://doi.org/10.1007/s13659-024-00443-1

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