A case of 5-fluorouracil toxicity

Dihydrouracil (UH2)/Uracil (U) ratio in plasma was determinated as a surrogate marker for dihydropyrimidine dehydrogenase (DPD) activity. The purpose of the study was to investigate the ralationship between the UH2/U plasma ratio and the variation of DPD gene (DPYD), associated with a deficiency of...

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Bibliographic Details
Main Authors: C. Fucile, V. Marini, L. Robbiano, F. Mattioli, A. Martelli
Format: Article
Language:English
Published: PAGEPress Publications 2011-01-01
Series:Journal of Biological Research
Online Access:http://www.pagepressjournals.org/index.php/jbr/article/view/4648