A case of 5-fluorouracil toxicity
Dihydrouracil (UH2)/Uracil (U) ratio in plasma was determinated as a surrogate marker for dihydropyrimidine dehydrogenase (DPD) activity. The purpose of the study was to investigate the ralationship between the UH2/U plasma ratio and the variation of DPD gene (DPYD), associated with a deficiency of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2011-01-01
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| Series: | Journal of Biological Research |
| Online Access: | http://www.pagepressjournals.org/index.php/jbr/article/view/4648 |
| _version_ | 1828399059849707520 |
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| author | C. Fucile V. Marini L. Robbiano F. Mattioli A. Martelli |
| author_facet | C. Fucile V. Marini L. Robbiano F. Mattioli A. Martelli |
| author_sort | C. Fucile |
| collection | DOAJ |
| description | Dihydrouracil (UH2)/Uracil (U) ratio in plasma was determinated as a surrogate marker for dihydropyrimidine dehydrogenase (DPD) activity. The purpose of the study was to investigate the ralationship between the UH2/U plasma ratio and the variation of DPD gene (DPYD), associated with a deficiency of DPD activity, in a patient who developed a severe adverse reaction to 5-fluorouracil. Patient's plasma smaple and those of 20 healthy volunteers, used as control, were analyzed. The plasma concentrations of UH2 and U were assayed by HPLC-UV. UH2/U plasma ratio of the patient was 4.31; the mean ± SD of UH2/U plasma ratios in controls was 5.26 ± 2.08. The UH2/U ratio of the patient was lower than the mean values recorded from a reference population suggesting a reduction of DPD activity according to haplotype of the patient, previously identified. |
| first_indexed | 2024-12-10T09:11:58Z |
| format | Article |
| id | doaj.art-cd643acaf5694015a62c45e25cf00c22 |
| institution | Directory Open Access Journal |
| issn | 1826-8838 2284-0230 |
| language | English |
| last_indexed | 2024-12-10T09:11:58Z |
| publishDate | 2011-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj.art-cd643acaf5694015a62c45e25cf00c222022-12-22T01:54:59ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302011-01-0184110.4081/jbr.2011.46483798A case of 5-fluorouracil toxicityC. FucileV. MariniL. RobbianoF. MattioliA. MartelliDihydrouracil (UH2)/Uracil (U) ratio in plasma was determinated as a surrogate marker for dihydropyrimidine dehydrogenase (DPD) activity. The purpose of the study was to investigate the ralationship between the UH2/U plasma ratio and the variation of DPD gene (DPYD), associated with a deficiency of DPD activity, in a patient who developed a severe adverse reaction to 5-fluorouracil. Patient's plasma smaple and those of 20 healthy volunteers, used as control, were analyzed. The plasma concentrations of UH2 and U were assayed by HPLC-UV. UH2/U plasma ratio of the patient was 4.31; the mean ± SD of UH2/U plasma ratios in controls was 5.26 ± 2.08. The UH2/U ratio of the patient was lower than the mean values recorded from a reference population suggesting a reduction of DPD activity according to haplotype of the patient, previously identified.http://www.pagepressjournals.org/index.php/jbr/article/view/4648 |
| spellingShingle | C. Fucile V. Marini L. Robbiano F. Mattioli A. Martelli A case of 5-fluorouracil toxicity Journal of Biological Research |
| title | A case of 5-fluorouracil toxicity |
| title_full | A case of 5-fluorouracil toxicity |
| title_fullStr | A case of 5-fluorouracil toxicity |
| title_full_unstemmed | A case of 5-fluorouracil toxicity |
| title_short | A case of 5-fluorouracil toxicity |
| title_sort | case of 5 fluorouracil toxicity |
| url | http://www.pagepressjournals.org/index.php/jbr/article/view/4648 |
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