Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis

Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis

Neutrophils are involved in the alveolitis of idiopathic pulmonary fibrosis (IPF). However, their pathogenic mechanisms are still poorly understood. Nintedanib has antifibrotic and anti-inflammatory activity in IPF. This study aimed to investigate the regulatory mechanism of nintedanib on neutrophil...

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Bibliographic Details
Main Authors: Wei-Chih Chen, Nien-Jung Chen, Hsin-Pai Chen, Wen-Kuang Yu, Vincent Yi-Fong Su, Hao Chen, Huai-Hsuan Wu, Kuang-Yao Yang
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
nintedanib
neutrophil
chemokine (C-X-C motif) receptor 2 (CXCR2)
G protein-coupled receptor kinase 2 (GRK2)
pulmonary fibrosis
Online Access:https://www.mdpi.com/1422-0067/21/13/4735

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https://www.mdpi.com/1422-0067/21/13/4735

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