Novel Multi-Target Agents Based on the Privileged Structure of 4-Hydroxy-2-quinolinone

Novel Multi-Target Agents Based on the Privileged Structure of 4-Hydroxy-2-quinolinone

In this work, the privileged scaffold of 4-hydroxy-2quinolinone is investigated through the synthesis of carboxamides and hybrid derivatives, as well as through their bioactivity evaluation, focusing on the ability of the molecules to inhibit the soybean LOX, as an indication of their anti-inflammat...

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Bibliographic Details
Main Authors: Ioanna Kostopoulou, Andromachi Tzani, Konstantina Chronaki, Kyriakos C. Prousis, Eleni Pontiki, Dimitra Hadjiplavlou-Litina, Anastasia Detsi
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
4-hydroxy-2-quinolinone
carboxamides
antioxidant activity
lipoxygenase inhibition
structure–activity relationships
molecular docking
Online Access:https://www.mdpi.com/1420-3049/29/1/190

Internet

https://www.mdpi.com/1420-3049/29/1/190

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