Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice

Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice

We previously explored a panel of adjuvants formulated with pre-fusion RSV-F protein and found that AS02 may be a promising candidate adjuvant for developing RSV-F subunit vaccines with improved immunogenicity and desired immune response type. In this study, we performed a head-to-head comparison of...

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Bibliographic Details
Main Authors: Lijun Bian, Yu Zheng, Xiaohong Guo, Dongdong Li, Jingying Zhou, Linyao Jing, Yan Chen, Jingcai Lu, Ke Zhang, Chunlai Jiang, Yong Zhang, Wei Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
respiratory syncytial virus
subunit vaccine
vaccine adjuvant
inoculation route
administration route
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.938598/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.938598/full

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