Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats

Pharmacokinetic Drug Interaction between Tofacitinib and Voriconazole in Rats

Fungal infections are prevalent in patients with immune diseases. Voriconazole, a triazole antifungal drug, inhibits the cytochromes CYP3A4 and CYP2C, and tofacitinib, a Janus kinase inhibitor for the treatment of rheumatoid arthritis, is metabolized by CYP3A4 and CYP2C19 in humans. Here, we investi...

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Bibliographic Details
Main Authors: Ji-Sang Lee, Hyo-Sung Kim, Yong-Seob Jung, Hyeon-Gyeom Choi, So-Hee Kim
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
tofacitinib
voriconazole
pharmacokinetics
non-competitive inhibition
CYP3A
CYP2C
Online Access:https://www.mdpi.com/1999-4923/13/5/740

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https://www.mdpi.com/1999-4923/13/5/740

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