Coinhibitory T-Cell Signaling in Islet Allograft Rejection and Tolerance
Autoaggressive T cells directed against insulin secreting pancreatic β-cells mediate the development of type 1 diabetes. Islet transplantation offers superior glycemic control over exogenous insulin, but chronic immunosuppression limits its broad application. Pathogenic T cells are also important in...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2006-02-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000006783982160 |