Novel sulphonamide-azaheterocycle conjugates and their anti-cancer, anti-inflammatory, anti-diabetic, anti-angiogenesis activity and molecular docking studies

Novel sulphonamide-azaheterocycle conjugates and their anti-cancer, anti-inflammatory, anti-diabetic, anti-angiogenesis activity and molecular docking studies

The present study reports the synthesis of sulphonamide-azaheterocycle conjugates (3 a-j) and evaluates its in vitro anticancer activity against breast cancer cell line (MCF-7) and liver cancer cell line (HepG2). The compound 3g was found to be the most active compound with IC50 values of 40.54 ± 0....

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Bibliographic Details
Main Authors:	Pradnya Patil, Nisha Nerlekar, Sanket Rathod, Pradeep Mhaldar, Taha Najm, Prakash Bansode, Jagannath Jadhav, Padma Dandge, Prafulla Choudhari, Dattaprasad Pore, Gajanan Rashinkar
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Series:	Results in Chemistry
Subjects:	Sulphonamide-azaheterocycle conjugates Anti-cancer DAPI Anti-inflammatory Anti-diabetic activity Antiangiogenic activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715624001723

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