Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes
Cyclooxygenase (COX), the primary enzyme responsible for the synthesis of prostanoids, exists in at least 2 isoforms. COX-2 has been suggested to be the isoform primarily responsible for synthesis of prostaglandins (PGs) in the context of inflammation. Thus, selective inhibitors of COX-2 were develo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Peoples’ Friendship University of Russia (RUDN University)
2009-03-01
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| Series: | RUDN Journal of Medicine |
| Online Access: | http://journals.rudn.ru/medicine/article/view/3776 |
| _version_ | 1811305792069959680 |
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| author | A V Pasechnik O N Semochkina E G Moiseeva |
| author_facet | A V Pasechnik O N Semochkina E G Moiseeva |
| author_sort | A V Pasechnik |
| collection | DOAJ |
| description | Cyclooxygenase (COX), the primary enzyme responsible for the synthesis of prostanoids, exists in at least 2 isoforms. COX-2 has been suggested to be the isoform primarily responsible for synthesis of prostaglandins (PGs) in the context of inflammation. Thus, selective inhibitors of COX-2 were developed with the aim that they would be as effective as traditional nonsteroidal antiinflammatory drugs (NSAIDs) but would not be as damaging to the gastrointestinal tract by virtue of not inhibiting the primarily COX-1-dependent PG synthesis in those tissues. To investigate whether selective COX 2 inhibitors would play a role in a model of inflammation. The received results testify to ability of COX 2 inhibitors to increase adhesion and modulation of apoptosis and PMN free oxygen radicals production. The drugs' effect on PMN free oxygen radicals production, apoptosis and adhesion may constitute an additional mechanism of their activity. These data characterize the potential mechanism to explain effects immunomodulatory agents of pathway and therapy for inflammation, cardiovascular diseases and bronchial asthma; beta-adrenergic receptors are functionally coupled to signalling cascades in human neutrophils
These results clearly confirmed that COX-2 plays a critical role in the development of the inflammatory response by altering key components of the inflammatory cascade. Therefore, selective inhibitor of COX-2 such as celecoxib, offers a therapeutic approach for the management of various inflammatory diseases. |
| first_indexed | 2024-04-13T08:32:42Z |
| format | Article |
| id | doaj.art-cd74f37058f347a184812ea8498f63bf |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-04-13T08:32:42Z |
| publishDate | 2009-03-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-cd74f37058f347a184812ea8498f63bf2022-12-22T02:54:12ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612009-03-01011031053776Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytesA V Pasechnik0O N Semochkina1E G Moiseeva2Российский университет дружбы народовРоссийский университет дружбы народовРоссийский университет дружбы народовCyclooxygenase (COX), the primary enzyme responsible for the synthesis of prostanoids, exists in at least 2 isoforms. COX-2 has been suggested to be the isoform primarily responsible for synthesis of prostaglandins (PGs) in the context of inflammation. Thus, selective inhibitors of COX-2 were developed with the aim that they would be as effective as traditional nonsteroidal antiinflammatory drugs (NSAIDs) but would not be as damaging to the gastrointestinal tract by virtue of not inhibiting the primarily COX-1-dependent PG synthesis in those tissues. To investigate whether selective COX 2 inhibitors would play a role in a model of inflammation. The received results testify to ability of COX 2 inhibitors to increase adhesion and modulation of apoptosis and PMN free oxygen radicals production. The drugs' effect on PMN free oxygen radicals production, apoptosis and adhesion may constitute an additional mechanism of their activity. These data characterize the potential mechanism to explain effects immunomodulatory agents of pathway and therapy for inflammation, cardiovascular diseases and bronchial asthma; beta-adrenergic receptors are functionally coupled to signalling cascades in human neutrophils These results clearly confirmed that COX-2 plays a critical role in the development of the inflammatory response by altering key components of the inflammatory cascade. Therefore, selective inhibitor of COX-2 such as celecoxib, offers a therapeutic approach for the management of various inflammatory diseases.http://journals.rudn.ru/medicine/article/view/3776 |
| spellingShingle | A V Pasechnik O N Semochkina E G Moiseeva Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes RUDN Journal of Medicine |
| title | Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes |
| title_full | Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes |
| title_fullStr | Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes |
| title_full_unstemmed | Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes |
| title_short | Inhibitors of cyclooxygenase-2-dependent modulation of functional characteristics of leukocytes |
| title_sort | inhibitors of cyclooxygenase 2 dependent modulation of functional characteristics of leukocytes |
| url | http://journals.rudn.ru/medicine/article/view/3776 |
| work_keys_str_mv | AT avpasechnik inhibitorsofcyclooxygenase2dependentmodulationoffunctionalcharacteristicsofleukocytes AT onsemochkina inhibitorsofcyclooxygenase2dependentmodulationoffunctionalcharacteristicsofleukocytes AT egmoiseeva inhibitorsofcyclooxygenase2dependentmodulationoffunctionalcharacteristicsofleukocytes |