Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

Abstract Background Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vivo, as well as the potential mechanisms. Methods The antitumor effect o...

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Bibliographic Details
Main Authors: Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai, Ming Xue
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lapachol
C6 glioma
Topoisomerase I
Topoisomerase II
Online Access:http://link.springer.com/article/10.1186/s13046-016-0455-3

Internet

http://link.springer.com/article/10.1186/s13046-016-0455-3

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