METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells

METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells

Abstract Background Ovarian cancer (OC) typically develops an immunosuppressive microenvironment by funtional changes of host immune cells. Dysregulated m6A level is associated with cancer progression via the intrinsic oncogenic pathways. However, the role of m6A in regulating host immune cell funct...

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Bibliographic Details
Main Authors: Jinyong Wang, Dakai Ling, Lulin Shi, Huayun Li, Minhua Peng, Huihong Wen, Tao Liu, Ruifang Liang, Yongjian Lin, Laiyou Wei, Guangzhi Zhang, Shanze Chen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell & Bioscience
Subjects:
METTL3
Myeloid-derived suppressive cells
Tumor microenvironment
Inflammatory responses
Ovarian cancer
m6A
Online Access:https://doi.org/10.1186/s13578-023-01149-6

Internet

https://doi.org/10.1186/s13578-023-01149-6

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