Factors Affecting Combination Trial Success (FACTS): Investigator Survey Results on Early-Phase Combination Trials

Factors Affecting Combination Trial Success (FACTS): Investigator Survey Results on Early-Phase Combination Trials

Experimental therapeutic oncology agents are often combined to circumvent tumor resistance to individual agents. However, most combination trials fail to demonstrate sufficient safety and efficacy to advance to a later phase. This study collected survey data on phase 1 combination therapy trials ide...

Full description

Bibliographic Details
Main Authors: Channing J. Paller, Erich P. Huang, Thomas Luechtefeld, Holly A. Massett, Christopher C. Williams, Jinxiu Zhao, Amy E. Gravell, Tami Tamashiro, Steven A. Reeves, Gary L. Rosner, Michael A. Carducci, Lawrence Rubinstein, S. Percy Ivy
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Medicine
Subjects:
clinical trials
combination therapy
regulatory approval
early phase
trial design
drug combinations
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00122/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2019.00122/full

Similar Items