A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Senescent cells can influence the tumour microenvironment by secreting immunomodulatory factors and are thus a therapeutic target. Here, the authors identify a compound that degrades BET leading to DNA damage and activation of autophagy and a reduction in tumour growth.

Bibliographic Details
Main Authors: Masahiro Wakita, Akiko Takahashi, Osamu Sano, Tze Mun Loo, Yoshinori Imai, Megumi Narukawa, Hidehisa Iwata, Tatsuyuki Matsudaira, Shimpei Kawamoto, Naoko Ohtani, Tamotsu Yoshimori, Eiji Hara
Format: Article
Language:English
Published: Nature Portfolio 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15719-6

Internet

https://doi.org/10.1038/s41467-020-15719-6

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