A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Senescent cells can influence the tumour microenvironment by secreting immunomodulatory factors and are thus a therapeutic target. Here, the authors identify a compound that degrades BET leading to DNA damage and activation of autophagy and a reduction in tumour growth.
Bibliographic Details
| Main Authors: |
Masahiro Wakita,
Akiko Takahashi,
Osamu Sano,
Tze Mun Loo,
Yoshinori Imai,
Megumi Narukawa,
Hidehisa Iwata,
Tatsuyuki Matsudaira,
Shimpei Kawamoto,
Naoko Ohtani,
Tamotsu Yoshimori,
Eiji Hara |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-15719-6
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