Investigation of the impact of rosuvastatin and telmisartan in doxorubicin-induced acute cardiotoxicity

Investigation of the impact of rosuvastatin and telmisartan in doxorubicin-induced acute cardiotoxicity

Cardiac injury is the main dose-limiting factor for doxorubicin (Dox) use as an anticancer agent. The cardiotoxicity of Dox is linked to a number of complex mechanisms, including oxidative stress, mitochondrial damage, intracellular calcium dysregulation, and apoptosis/necrosis. This study investiga...

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Bibliographic Details
Main Authors: Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Afrah Fahad Alkhuriji, Wafa Abdullah I. Al-Megrin, Engy Elekhnawy, Walaa A. Negm, Michel De Waard, Gaber El-Saber Batiha
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cardiac troponin-I
Histopathology
Interleukin-17
Malondialdehyde
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222010629

Internet

http://www.sciencedirect.com/science/article/pii/S0753332222010629

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