Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting

Subcellular mRNA kinetic modeling reveals nuclear retention as rate-limiting

Abstract Eukaryotic mRNAs are transcribed, processed, translated, and degraded in different subcellular compartments. Here, we measured mRNA flow rates between subcellular compartments in mouse embryonic stem cells. By combining metabolic RNA labeling, biochemical fractionation, mRNA sequencing, and...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: David Steinbrecht, Igor Minia, Miha Milek, Johannes Meisig, Nils Blüthgen, Markus Landthaler
स्वरूप: लेख
भाषा:English
प्रकाशित: Springer Nature 2024-11-01
श्रृंखला:Molecular Systems Biology
विषय:
RNA Dynamics
Kinetic Modeling
Subcellular Fractionation
Nuclear Retention
Metabolic Labeling
ऑनलाइन पहुंच:https://doi.org/10.1038/s44320-024-00073-2

इंटरनेट

https://doi.org/10.1038/s44320-024-00073-2

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