Smart osteoclasts targeted nanomedicine based on amorphous CaCO3 for effective osteoporosis reversal

Smart osteoclasts targeted nanomedicine based on amorphous CaCO3 for effective osteoporosis reversal

Abstract Background Osteoporosis is characterized by an imbalance in bone homeostasis, resulting in the excessive dissolution of bone minerals due to the acidified microenvironment mediated by overactive osteoclasts. Oroxylin A (ORO), a natural flavonoid, has shown potential in reversing osteoporosi...

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Bibliographic Details
Main Authors: Biao Yu, Qianmin Gao, Shihao Sheng, Fengjin Zhou, Zhen Geng, Yan Wei, Hao Zhang, Yan Hu, Sicheng Wang, Jianping Huang, Mengmeng Li, Jiacan Su
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
pH responsiveness
Oroxylin A
Osteoporosis
Acidic microenvironment
Synergistic therapy
Online Access:https://doi.org/10.1186/s12951-024-02412-9

Internet

https://doi.org/10.1186/s12951-024-02412-9

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