Erythrocyte Folyl Polyglutamate Synthetase Activity Profiling as a Potential Tool for the Prediction of Methotrexate Efficacy and Toxicity in Rheumatoid Arthritis

Erythrocyte Folyl Polyglutamate Synthetase Activity Profiling as a Potential Tool for the Prediction of Methotrexate Efficacy and Toxicity in Rheumatoid Arthritis

Methotrexate (MTX) is the cornerstone of therapy in the treatment of rheumatoid arthritis (RA). However, its efficacy and toxicity are variable and remain unpredictable. Interindividual variation in the metabolism of MTX by the enzyme folyl polyglutamate synthetase (FPGS) has been associated with re...

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Bibliographic Details
Main Authors: Amar Kumar, Mudassar Iqbal Arain, Pooja Bhadbhade, Ryan Funk
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Future Pharmacology
Subjects:
methotrexate
FPGS
rheumatoid arthritis
enzyme kinetics
therapeutic drug monitoring
biomarker
Online Access:https://www.mdpi.com/2673-9879/3/4/49

Internet

https://www.mdpi.com/2673-9879/3/4/49

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