In Vitro Study of Cytotoxic Mechanisms of Alkylphospholipids and Alkyltriazoles in Acute Lymphoblastic Leukemia Models

In Vitro Study of Cytotoxic Mechanisms of Alkylphospholipids and Alkyltriazoles in Acute Lymphoblastic Leukemia Models

This study investigates the efficacy of miltefosine, alkylphospholipid, and alkyltriazolederivative compounds against leukemia lineages. The cytotoxic effects and cellular and molecular mechanisms of the compounds were investigated. The inhibitory potential and mechanism of inhibition of cathepsins...

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Bibliographic Details
Main Authors: Larissa de Oliveira Passos Jesus, Aline Aparecida de Souza, Heron Fernandes Vieira Torquato, Vanessa Silva Gontijo, Rossimirian Pereira de Freitas, Tarsis Ferreira Gesteira, Vivien Jane Coulson-Thomas, Ricardo José Soares Torquato, Aparecida Sadae Tanaka, Edgar Julian Paredes-Gamero, Wagner Alves de Souza Judice
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
alkylphospholipids
alkyltriazoles
cell death
acute lymphoblastic leukemia
cathepsin inhibition
Online Access:https://www.mdpi.com/1420-3049/27/23/8633

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https://www.mdpi.com/1420-3049/27/23/8633

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