Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Direct imaging of hippocampal epileptiform calcium motifs following kainic acid administration in freely behaving mice

Prolonged exposure to abnormally high calcium concentrations is thought to be a core mechanism underlying hippocampal damage in epileptic patients; however, no prior study has characterized calcium activity during seizures in the live, intact hippocampus. We have directly investigated this possibili...

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Bibliographic Details
Main Authors: Tamara K Berdyyeva, E. Paxon eFrady, Jonathan J Nassi, Leah eAluisio, Yauheniya eCherkas, Stephani eOtte, Ryan M Wyatt, Christine eDugovic, Kunal K Ghosh, Mark J Schnitzer, Timothy eLovenberg, Pascal eBonaventure
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Neuroscience
Subjects:
Electroencephalography
Kainic Acid
seizure
calcium imaging
GCaMP6
freely behaving mice
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00053/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00053/full

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