An interaction-based drug discovery screen explains known SARS-CoV-2 inhibitors and predicts new compound scaffolds

Abstract The recent outbreak of the COVID-19 pandemic caused by severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) has shown the necessity for fast and broad drug discovery methods to enable us to react quickly to novel and highly infectious diseases. A well-known SARS-CoV-2 target is the...

Full description

Bibliographic Details
Main Authors: Philipp Schake, Klevia Dishnica, Florian Kaiser, Christoph Leberecht, V. Joachim Haupt, Michael Schroeder
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35671-x