rHDL modeling and the anchoring mechanism of LCAT activation

Lecithin:cholesterol-acyl transferase (LCAT) plays a major role in cholesterol metabolism as it is the only extracellular enzyme able to esterify cholesterol. LCAT activity is required for lipoprotein remodeling and, most specifically, for the growth and maturation of HDLs. In fact, genetic alterati...

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Bibliographic Details
Main Authors: Tommaso Laurenzi, Chiara Parravicini, Luca Palazzolo, Uliano Guerrini, Elisabetta Gianazza, Laura Calabresi, Ivano Eberini
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520437083