The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation

The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation

Abstract Pediatric Acute Myeloid Leukemia (AML) is a rare and heterogeneous disease characterized by a high prevalence of gene fusions as driver mutations. Despite the improvement of survival in the last years, about 50% of patients still experience a relapse. It is not possible to improve prognosis...

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Bibliographic Details
Main Authors: Joan Domingo-Reinés, Rosa Montes, Adrián Garcia-Moreno, Amador Gallardo, Jose Manuel Sanchez-Manas, Iván Ellson, Mar Lamolda, Chiara Calabro, Jose Antonio López-Escamez, Purificación Catalina, Pedro Carmona-Sáez, Pedro J. Real, David Landeira, Verónica Ramos-Mejia
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05870-5

Internet

https://doi.org/10.1038/s41419-023-05870-5

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