PGF2α induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF2α receptor antagonists

PGF2α induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF2α receptor antagonists

Preterm birth is the leading cause of infant morbidity and mortality. There has been an interest in developing prostaglandin F2α (PGF2α) antagonists as a new treatment for preterm birth, although much of the rationale for their use is based on studies in rodents where PGF2α initiates labour by regre...

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Bibliographic Details
Main Authors: Isabel Hamshaw, Anne Straube, Richard Stark, Laura Baxter, Mohammad T. Alam, Walter J. Wever, Jun Yin, Yong Yue, Philippe Pinton, Aritro Sen, Gregory D. Ferguson, Andrew M. Blanks
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Pharmacology
Subjects:
myometrium
PGF2α
FP receptor
FP antagonists
smooth muscle
labour
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1285779/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1285779/full

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