Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells

Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells

Abstract Small‐Cell Lung Cancer (SCLC) is an aggressive neuroendocrine malignancy with a poor prognosis. Here, we focus on the neuroendocrine SCLC subtypes, SCLC‐A and SCLC‐N, whose transcription addiction was driven by ASCL1 and NEUROD1 transcription factors which target E‐box motifs to activate up...

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Bibliographic Details
Main Authors: Federico Costanzo, Marta Martínez Diez, Gema Santamaría Nuñez, Juan Ignacio Díaz‐Hernandéz, Carlos Mario Genes Robles, Javier Díez Pérez, Emmanuel Compe, Romeo Ricci, Tsai‐Kun Li, Frédéric Coin, Juan Fernando Martínez Leal, Eva Maria Garrido‐Martin, Jean Marc Egly
Format: Article
Language:English
Published: Springer Nature 2022-03-01
Series:EMBO Molecular Medicine
Subjects:
ASCL1/NEUROD1
E‐boxes/CpG islands
lurbinectedin
transcription addiction
Online Access:https://doi.org/10.15252/emmm.202114841

Internet

https://doi.org/10.15252/emmm.202114841

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