Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging.

Mitochondrial DNA (mtDNA) mutations lead to decrements in mitochondrial function and accelerated rates of these mutations has been linked to skeletal muscle loss (sarcopenia). The purpose of this study was to investigate the effect of mtDNA mutations on mitochondrial quality control processes in ske...

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Bibliographic Details
Main Authors: Anna-Maria Joseph, Peter J Adhihetty, Nicholas R Wawrzyniak, Stephanie E Wohlgemuth, Anna Picca, Gregory C Kujoth, Tomas A Prolla, Christiaan Leeuwenburgh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3720551?pdf=render

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http://europepmc.org/articles/PMC3720551?pdf=render

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