2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli

2,4-Disubstituted pyridine derivatives are effective against intracellular and biofilm-forming tubercle bacilli

It was recently reported that 4-substituted picolinohydrazonamides carrying hydrophilic cyclic amines, such as morpholine and pyrrolidine, at the end of their thiosemicarbazide chain have potent antimycobacterial activity in vitro at concentrations below 1 μg/ml. Here, two selected compounds, 2,4-di...

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Bibliographic Details
Main Authors: M. Korycka-Machała, M. Kawka, J. Lach, R. Płocińska, A. Bekier, B. Dziadek, A. Brzostek, P. Płociński, D. Strapagiel, M. Szczesio, K. Gobis, J. Dziadek
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
pyridine derivatives
tuberculosis
drug resistance
Mtb inhibitors
MmpR5
biofilm
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1004632/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1004632/full

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