Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions

Abstract Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson’s disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation...

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Bibliographic Details
Main Authors: Meraj Ramezani, Alice Wagenknecht-Wiesner, Tong Wang, David A. Holowka, David Eliezer, Barbara A. Baird
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00578-x