MUS81 Inhibition Enhances the Anticancer Efficacy of Talazoparib by Impairing ATR/CHK1 Signaling Pathway in Gastric Cancer

MUS81 Inhibition Enhances the Anticancer Efficacy of Talazoparib by Impairing ATR/CHK1 Signaling Pathway in Gastric Cancer

MUS81 is a critical endonuclease involved in heterodimer formation with Eme1/Mms4 and an important DNA damage repair regulatory molecule. Our previous study suggested that MUS81 was overexpressed and its high expression was positively correlated with gastric cancer metastasis. However, the therapeut...

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Bibliographic Details
Main Authors: Tao Wang, Peng Zhang, Chengguo Li, Weizhen Liu, Qian Shen, Lei Yang, Gengchen Xie, Jie Bai, Ruidong Li, Kaixiong Tao, Yuping Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
gastric cancer
MUS81
PARP inhibitor
BRD4 inhibitor
DNA damage
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.844135/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.844135/full

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