RelB-activated GPX4 inhibits ferroptosis and confers tamoxifen resistance in breast cancer

RelB-activated GPX4 inhibits ferroptosis and confers tamoxifen resistance in breast cancer

Tamoxifen (TAM) resistance remains a major obstacle in the treatment of advanced breast cancer (BCa). In addition to the competitive inhibition of the estrogen receptor (ER) signaling pathway, damping of mitochondrial function by increasing reactive oxygen species (ROS) is critical for enhancing TAM...

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Bibliographic Details
Main Authors: Zhi Xu, Xiumei Wang, Wenbo Sun, Fan Xu, Hengyuan Kou, Weizi Hu, Yanyan Zhang, Qin Jiang, Jinhai Tang, Yong Xu
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Redox Biology
Subjects:
Tamoxifen resistance
Breast cancer
ROS
Ferroptosis
GPX4
RelB
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723003531

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http://www.sciencedirect.com/science/article/pii/S2213231723003531

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