Low cellular pyridoxal 5ʹ-phosphate levels decrease neurotransmitter and glutathione concentrations and increase susceptibility to hydrogen peroxide toxicity in SH-SY5Y cells

Low cellular pyridoxal 5ʹ-phosphate levels decrease neurotransmitter and glutathione concentrations and increase susceptibility to hydrogen peroxide toxicity in SH-SY5Y cells

Summary: Objectives: Pyridoxal 5ʹ-phosphate (PLP) is an active and major form of vitamin B6 (VB6) in the body. PLP is essential as a cofactor for many enzymes involved in amino acid metabolism, and VB6 deficiency is associated with neurological disorders, such as epileptic-like symptoms, depression...

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Bibliographic Details
Main Authors: Nana Itoh, Shigenobu Matsumura, Toshio Iwaki, Shigeo Takenaka, Hiroaki Kanouchi
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Clinical Nutrition Open Science
Subjects:
Pyridoxal 5ʹ-phosphate
SH-SY5Y
Neurotransmitter
Glutathione
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2667268524000251

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http://www.sciencedirect.com/science/article/pii/S2667268524000251

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