Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase

Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase

ABSTRACTType II topoisomerase utilizes the energy from ATP hydrolysis to alter DNA topology during genome replication and transcription. The ATPase domain of this enzyme is required for ATP hydrolysis and plays a crucial role in coupling DNA binding and ATP turnover with the DNA strand passage react...

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Bibliographic Details
Main Authors: Wenhua Kuang, Yan Zhao, Jinyue Li, Zengqin Deng
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
African swine fever virus
topoisomerase
ATPase domain
crystal structure
Online Access:https://journals.asm.org/doi/10.1128/mbio.03086-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03086-23

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