Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans.
Amino acids are among the earliest identified inducers of yeast-to-hyphal transitions in Candida albicans, an opportunistic fungal pathogen of humans. Here, we show that the morphogenic amino acids arginine, ornithine and proline are internalized and metabolized in mitochondria via a PUT1- and PUT2-...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-02-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC6386415?pdf=render |