An In-Vitro Study of the Expansion and Transcriptomics of CD<sup>4+</sup> and CD<sup>8+</sup> Naïve and Memory T Cells Stimulated by IL-2, IL-7 and IL-15

An In-Vitro Study of the Expansion and Transcriptomics of CD<sup>4+</sup> and CD<sup>8+</sup> Naïve and Memory T Cells Stimulated by IL-2, IL-7 and IL-15

The growth of T cells ex vivo for the purpose of T cell therapies is a rate-limiting step in the overall process for cancer patients to achieve remission. Growing T cells is a fiscally-, time-, and resource-intensive process. Cytokines have been shown to accelerate the growth of T cells, specificall...

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Bibliographic Details
Main Authors: Brooks Hopkins, Justin Fisher, Meiping Chang, Xiaoyan Tang, Zhimei Du, William J. Kelly, Zuyi Huang
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
IL-2
IL-7
IL-15
T cell therapy
T cell subsets
RNA-sequencing
Online Access:https://www.mdpi.com/2073-4409/11/10/1701

Internet

https://www.mdpi.com/2073-4409/11/10/1701

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