Many-to-one comparisons after safety selection in multi-arm clinical trials.

In phase II platform trials, 'many-to-one' comparisons are performed when K experimental treatments are compared with a common control to identify the most promising treatment(s) to be selected for Phase III trials. However, when sample sizes are limited, such as when the disease of intere...

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Bibliographic Details
Main Authors: Gerald Hlavin, Lisa V Hampson, Franz Koenig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5484516?pdf=render