A common pathway for detergent-assisted oligomerization of Aβ42

A common pathway for detergent-assisted oligomerization of Aβ42

Abstract Amyloid beta (Aβ) aggregation is a slow process without seeding or assisted nucleation. Sodium dodecyl sulfate (SDS) micelles stabilize Aβ42 small oligomers (in the dimer to tetramer range); subsequent SDS removal leads to a 150-kD Aβ42 oligomer. Dodecylphosphorylcholine (DPC) micelles also...

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Bibliographic Details
Main Authors: Fidha Nazreen Kunnath Muhammedkutty, Ramesh Prasad, Yuan Gao, Tarunya Rao Sudarshan, Alicia S. Robang, Jens O. Watzlawik, Terrone L. Rosenberry, Anant K. Paravastu, Huan-Xiang Zhou
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05556-w

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https://doi.org/10.1038/s42003-023-05556-w

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