Eudebeiolide B Inhibits Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Regulating RANKL-Induced NF-κB, c-Fos and Calcium Signaling

Eudebeiolide B Inhibits Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Regulating RANKL-Induced NF-κB, c-Fos and Calcium Signaling

Eudebeiolide B is a eudesmane-type sesquiterpenoid compound isolated from <i>Salvia plebeia</i> R. Br., and little is known about its biological activity. In this study, we investigated the effects of eudebeiolide B on osteoblast differentiation, receptor activator nuclear factor-κB liga...

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Bibliographic Details
Main Authors: Mi-Hwa Kim, Hyung-Jin Lim, Seon Gyeong Bak, Eun-Jae Park, Hyun-Jae Jang, Seung Woong Lee, Soyoung Lee, Kang Min Lee, Sun Hee Cheong, Seung-Jae Lee, Mun-Chual Rho
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceuticals
Subjects:
eudebeiolide B
osteoporosis
RANKL
OVX mouse model
calcium signal
Online Access:https://www.mdpi.com/1424-8247/13/12/468

Internet

https://www.mdpi.com/1424-8247/13/12/468

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