Implications of O-glycan modifications in the hinge region of a plant-produced SARS-CoV-2-IgA antibody on functionality

Implications of O-glycan modifications in the hinge region of a plant-produced SARS-CoV-2-IgA antibody on functionality

Introduction: Prolyl-4-hydroxylases (P4H) catalyse the irreversible conversion of proline to hydroxyproline, constituting a common posttranslational modification of proteins found in humans, plants, and microbes. Hydroxyproline residues can be further modified in plants to yield glycoproteins contai...

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Main Authors: Pia Uetz, Kathrin Göritzer, Emil Vergara, Stanislav Melnik, Clemens Grünwald-Gruber, Rudolf Figl, Ala-Eddine Deghmane, Elisabetta Groppelli, Rajko Reljic, Julian K.-C. Ma, Eva Stöger, Richard Strasser
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
antibody
glycoprotein
glycosylation
Nicotiana benthamiana
posttranslational modification
virus
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1329018/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1329018/full

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