A Comparative Study to Evaluate the Effect of Different Carbohydrates on the Stability of Immunoglobulin G during Lyophilization and Following Storage

A Comparative Study to Evaluate the Effect of Different Carbohydrates on the Stability of Immunoglobulin G during Lyophilization and Following Storage

Background: Although the stabilizing effects of cyclodextrins (CDs) on the liquid protein formulations have been proven, there is no comprehensive data on evaluation of their effects on the lyophilized antibody powders. In this study, the influence of two CD derivatives namely beta-cyclodextrin (βCD...

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Bibliografiske detaljer
Hovedforfatter: Homa Faghihi 1, Sara Merrikhihaghi 1, Abdolhosein Ruholamini Najafabadi 1, Vahid Ramezani 2, Soroush Sardari 3, Alireza Vatanara 1 *
Format: Article
Sprog:English
Udgivet: Tabriz University of Medical Sciences 2016-12-01
Serier:Pharmaceutical Sciences
Fag:
Antibody
Lyophilization
Mannitol
Trehalose
Cyclodextrins
Stability
Online adgang:http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_4075_20160317105357

Internet

http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_4075_20160317105357

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